I have had a very painful knot on the knuckle of my thumb, which my chiropractor said was arthritis, and was really bothering me. It stuck out like a sore thumb! (I had to do that) After listening to Dr. Ardis, I bought some nicotine patches, cut them up as directed by him, and began using them, starting last Monday late morning. By 5:00 p.m. I noticed the pain was much less. By Friday, the pain was GONE, and the knot wasn’t even tender anymore. AND the knot is shrinking! Hallelujah!